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KMID : 0370219980420010012
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Yakhak Hoeji
1998 Volume.42 No. 1 p.12 ~ p.24
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Synthesis and Biological Activity of 3 - ( Substituted ) Tetrazolylmethyl Cephalosporins
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고옥현/Ko OH
김영수/고봉석/이재영/하재천/방희재/유진철/강형룡/Kim YS/Ko BS/Lee JY/Ha JC/Bang HJ/Yoo JC/Kang HR
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Abstract
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For the development of new cephalosporin antibiotics with aminothiazolcarboxymethylethoxyimino moiety on the C-7 position and tetrazolymethyl moiety on the C-3 position of cephe m ring, 70-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-[5-(substituted)tetrazol-2-yl]methyl-3-cephem-4-carboxylic acids(28-35) were synthesized. These compounds were tested for antimicrobial activity in vitro against Gram(+) and Gram(-) bacteria. They showed remarkable antibacterial activity against Escherichia coli AB 1157, Escherichia coli AB 0111, Escherichia coli BE 1186, Micrococcus luteus ATCC 9341, Salmonella typhimurium TV 119, Salmonella typhimurium SL 1102, Staphylococcus aureus IFO 12732, Staphylococcus aureus R-209, but these compounds were not active against Pseudomonas aeruginosa N-10.
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KEYWORD
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